Thursday, March 7, 2013

What killed Neanderthals? Blame those rascally rabbits

Patrick Pleul / EPA

The inability to catch small prey, such as wild rabbits, may have contributed to Neanderthal extinction.

By Nidhi Subbaraman

Neanderthals were big-game hunters who feasted on mammoth and rhino but didn?t or couldn?t eat smaller, leaner meat. Their picky diet ? or limited hunting skills ? could have made them vulnerable when mammal populations shrank and their favorite dinner became harder to find.

A broad survey of animal remains recorded at early human and Neanderthal sites across Spain, Portugal and France gives us new insight as to what humans and Neanderthals ate. One trend stuck out to scientists who assembled the data: Rabbit remains became much more popular at human sites just about the time that Neanderthals disappeared, about 30,000 years ago.


?Given how common bunnies would have been in that area, the trend hints that Neanderthals did not adapt their diet to include them. After all, the evidence suggests, early humans seem to have made the switch.

There?s no data to explain this trend, but there are theories. Neanderthals may have avoided rabbit dinners because they lacked the technology to catch them, says John Stewart, who studies fossil records and ancient climate at Bournemouth University.

?With modern humans, you see technology that allows them to catch smaller or faster-moving prey,? Stewart told NBC News. That? leads to the ?strong possibility? that humans were more efficient than Neanderthals at catching smaller but faster animals. Stewart and his collaborators explain their findings in a paper in the Journal of Human Evolution.

Of course, Neanderthals didn?t just live in Iberia. And in n other parts of the world, there?s evidence to show that they were catching seals and fish and mussels, and even birds.

But Stewart believes that the rabbit diet story is an indication of challenges Neanderthals faced all over the world. ?I think the rabbit was just a symptom [of their extinction] rather than the cause,? Stewart says. ?Neanderthals were more vulnerable because they had less tricks up their sleeve, less breadth of possibilities.?

More about Neanderthal histories:?


Via New Scientist

Nidhi Subbaraman writes about science and technology. Follow on Twitter, Google+.?

Source: http://science.nbcnews.com/_news/2013/03/06/17208416-what-killed-neanderthals-blame-those-rascally-rabbits?lite

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Monday, March 4, 2013

Snapshots and Dinosaurs: The Offices of Photojojo

Snapshots and Dinosaurs: The Offices of PhotojojoSome companies forego the boring cubicles and put some real thought into the design and atmosphere of their offices. Such is the case with Photojojo, who decorated their space with?unsurprisingly?plenty of photo snapshots. To liven things up a bit more, you'll be hard-pressed to look in any direction without finding some kind of dinosaur.

Aside from the designer blow ups and figurines you'll find around the office, Photojojo keeps things bright and happy with bold color accents. The office itself is simply white, but simple furniture and a little color go a long way. To see the entire office tour, be sure to check out the full post over at Apartment Therapy Tech.

If you have a workspace of your own to show off, add it to the Lifehacker Workspace Showcase. Be sure to include some details about your setup and why it works for you, and you just might see it featured on the front page of Lifehacker.

Photojojo's Fun Photo-Filled Space | Apartment Therapy Tech

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/8dy5y5d3V5w/snapshots-and-dinosaurs-the-offices-of-photojojo

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Police chief apologizes to Freedom Rider congressman

Decades after "Bloody Sunday," national leaders acknowledged America's continuing civil rights struggle by making the iconic march from Selma, Ala. to Montgomery. NBC's Lester Holt reports.

?

By Craig Giammona, NBC News

An Alabama police chief brought Rep. John Lewis to tears Saturday, apologizing to the noted civil rights leader for failing to protect the Freedom Riders during a trip to Montgomery in 1961.

Lewis and fellow civil rights activists were beaten by a mob after arriving at Montgomery's Greyhound station in May 1961.

On Saturday at ceremony at First Baptist Church, the city's current police chief, Kevin Murphy, apologized to Lewis and offered him his badge in a gesture of reconciliation, telling the longtime Georgia congressman that Montgomery police had "enforced unjust laws" in failing to protect the Freedom Riders more than five decades ago.


Lewis, who was arrested during civil rights protests in cities across the south, said it was the first time a police chief had apologized to him.

"It means a great deal," Lewis said. "I teared up. I tried to keep from crying."

Lewis and other members of Congress were taking part in the 13th Congressional Civil Rights Pilgrimage to Alabama, a three-day event that also included trips to Selma, Tuscaloosa and Birmingham.

Murphy said the decision to apologize was easy.

"For me, freedom and the right to live in peace is a cornerstone of our society and that was something that Martin Luther King, Rosa Parks and Congressman Lewis were trying to achieve" Murphy said. "I think what I did today should have been done a longtime ago. It needed to be done. It needed to be spoken because we have to live with the truth and it is the truth."

Murphy, who was asked to speak at the event only after Montgomery's mayor and director of public safety were unable to attend, said he wanted the Montgomery Police Department to be "heard in a different light than what history has recorded in years past."

"We're going to move forward as one Montgomery, one MPD. And we're going to continue to work at it," Murphy said. "There's still a lot of work to do, we know that. We, the police department, needs to make the first move to build that trust back in our community that was once lost because we enforced unjust laws.

"Those unjust laws were immoral and wrong. But you know what? It's a new day. And there's a new police department and a new Montgomery here and now and on the horizon."

Montgomery Police Chief Kevin Murphy and Rep. John Lewis speak to the press after Murphy offered an apology to Lewis for the failure of Montgomery police officers to respond to attacks on the Freedom Riders during a trip to Montgomery in May 1961.

Source: http://usnews.nbcnews.com/_news/2013/03/03/17167907-alabama-police-chief-apologizes-to-freedom-rider-congressman?lite

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Afghanistan after 11 years of US combat: 'Not much different'

Photo by Daniel Berehulak / Getty Images

Traffic moves through the old city in November, 2012, in Kabul, Afghanistan.

By Mike Taibbi, Correspondent, NBC News

KABUL, Afghanistan --? I wondered, approaching Kabul over the snow-shrouded Hindu Kush mountains, what the story of the moment would be in the teeming city below.?

It had been six years since I?d last visited Afghanistan?s capital, a short visit then that included an interview with President Hamid Karzai as part of the last of six long reporting assignments since 9/11? that one stretching from Paktika and Gardez in the southeast to Herat in the west.?

Mike Taibbi / NBC News

A spectacular view over the snow-covered Hindu Kush peaks on the way into Kabul.

More than 11 years had passed since my first Afghan assignment, over the Kyber Pass from Pakistan and then into Jalalabad days after the Taliban had fled;? the arc of America?s longest war.

?Not much different,? offered my seatmate, a senior NATO official from one of the 40 countries remaining in the coalition that has alternately steered or suffered through Afghanistan?s bloody march toward stand-alone status as a reconstituted nation.

?You?ll see some new construction under way in the city, but on the surface it?ll be little changed from what you saw before.?

Driving to our quarters, I found myself playing an old game: peering at the cars huffing and puffing along the city?s crowded streets, I counted the number of women drivers.? And got the same answer I?d counted on most days, 11 years ago.

Zero.

* ?* * * *

That so few women drive ? cars, bicycles, any conveyance where they are unaccompanied by men ? is a relatively small fact of life here but it?s emblematic. ?

Afghanistan is still waiting for the changes that will signal that a threshold has been reached, and a fundamental change in the status of women, and in their prospects after the 2014 withdrawal of most coalition combat troops, is one of the changes that matter.

Mike Taibbi / NBC News

Kimberly Motley, an American lawyer, has been living and working in Afghanistan for the past five years as an advocate for abused women.

It?s women who will suffer most after the withdrawal, said Kimberly Motley, an American lawyer living and working in Afghanistan for the past five years as an advocate for abused women.?

?I?ve been surprised that it?s been mostly men now clamoring desperately for a way to leave, when it?s women who will be affected so profoundly," she said. ?

With NATO forces gone they?ll have far less protection, she told us, while even under the limited protection that now exists there have been attacks against women so savage as to have commanded headlines worldwide.?

It?s been a consensus in the international community that this poorest and most corrupt of countries may yet be welcomed fully as a sovereign nation, but only when its women are treated with dignity and as equals under law and custom. While serving as secretary of state in 2001, Colin Powell stressed that women's rights were ?non-negotiable.?

* * * * *?

As for negotiations for peace and reconciliation with the Taliban, they are, for all practical purposes, non-existent.? A handful of self-described representatives of Taliban leadership have set up office space in Doha, Qatar, and overtures have been made with the goal of starting substantive talks.

?But here?s the problem,? a highly placed Western diplomat told me, asking that he not be identified.? ?Karzai only wants face-to-face discussions with the Taliban, at the negotiating table ? and not with interlocutors who may or may not represent Mullah Mohammed?Omar and the true Taliban leadership.? He?s not interested in discussing theoretical possibilities, if nothing of consequence is going to happen.?

The Taliban, meanwhile, seem uninterested in discussing any possibilities short of a return to complete power in Afghanistan.?

Said Maulvi Shahabuddin Dilawar, one of the Taliban's ?negotiators? in Doha, there will be a ?snowball effect? after the 2014 withdrawal, the Taliban waiting patiently to make their move.?

?Anything short of a total victory,? he said, ?is unacceptable.??? There?s a saying here, attributed to the Taliban:? ?They have the weapons; we have the time.?

Still, the Western diplomat said, ?We?ve opened a door in Doha, and hopefully there will be an answer and real negotiations might begin.??

I reminded him of the timeworn political clich?, ?Hope is not a strategy.??

He smiled. "Well, it?s more than mere hope," he said.

The diplomat talked about advances on the periphery of the central questions about peace talks and post-2014 security:? an imminent new mining law that will encourage foreign investors to ante in for a stake in the trillion dollars in copper, iron, gold and oil reserves within reach beneath this country?s battered landscape; ?advances despite notable setbacks in the training and readiness of Afghanistan?s army and national police forces; real improvements in the prospects for some women -- in medicine, law and even the armed services.??

?It?s not just hope,? the diplomat repeated.

* * * * *?

An old friend named Shirzad came by to visit on Saturday. ?He had worked for NBC News in the past and asked that we not use his family name for security reasons. ?

We talked about the days and months just after 9/11, when we first met, when in his home city of Jalalabad the Taliban had suddenly fled under the punishment of American bombing raids, and the eventual insertion of American special forces chasing Bin Laden and his surrogates through the mountains and caves of Tora Bora.?

There were so many signs of optimism then: little girls lining up giddily to go to school, some women braving the markets having shed their burqas, talk among the men about a new future when none had seemed possible for so many years.

Rahmat Gul / AP

More than ten years after the beginning of the war, Afghanistan faces external pressure to reform as well as ongoing internal conflicts.

But that future had not arrived, Shirzad said.? The Taliban were a ?shadow government? in so many villages and neighborhoods, in control by implication and threat, just waiting.?

?My family, and many of those I work with, we have been threatened with death.?? So he?s leaving, he says, having spent months negotiating a labyrinth of paperwork to gain approval to take his family of nine to the U.S. and take his chances there if he can.?

His brother, with his family of eight, is trying for the same option.? ?It is the only way for me,? he told me.? ?The local police, they will not protect us when NATO soldiers are gone ? many are Taliban or support them.??

He offered a sad smile: ?No more for me, in Afghanistan.?

What there is, he said, is corruption and danger in every direction.? Away from Kabul there were still drug lords ruling over fiefdoms fueled by flourishing poppy fields. Even in Kabul, he said, travel can be treacherous, trust unwise.

And Kimberly Motley has more clients than she can handle.

And 30 local police died in a two-day period last week in three suicide attacks for which the Taliban claimed credit.

And President Karzai complains about not getting enough American weapons and support, while at the same time ordering that American and NATO forces withdraw from a Kabul suburb because of unconfirmed rumors of harassment and attacks against civilians.

And in my third trip through the streets of a city I hadn?t seen in years, I looked again for any women drivers.

And couldn't find a single one. Again.

Related:

Ultimate taboo: Actress takes on rape in Afghanistan

Meet Afghanistan's first female rapper

As Taliban regroup, victims battle for 'free' Afghanistan

Source: http://worldnews.nbcnews.com/_news/2013/03/04/17180141-afghanistan-following-11-years-of-us-combat-not-much-different?lite

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Evernote forcing users to change password after hacking attempt

Evernote

Evernote, the popular cross-platform note taking and sharing app, has issued a statement about some recent "suspicious activity on the Evernote network". All users will have to change their password, and it seems that user names, and other data that includes the encrypted version of passwords has been accessed. In a letter sent out to users, Evernote says the following:

The investigation has shown, however, that the individual(s) responsible were able to gain access to Evernote user information, which includes usernames, email addresses associated with Evernote accounts, and encrypted passwords. Even though this information was accessed, the passwords stored by Evernote are protected by one-way encryption. (In technical terms, they are hashed and salted.)

While our password encryption measures are robust, we are taking steps to ensure your personal data remains secure. This means that in an abundance of caution, we are requiring all users to reset their Evernote account passwords. Please create a new password by signing into your account on evernote.com.

After signing in, you will be prompted to enter your new password. Once you have reset your password on evernote.com, you will need to enter this new password in other Evernote apps that you use. We are also releasing updates to several of our apps to make the password change process easier, so please check for updates over the next several hours.

As we've seen recently, there's a rash of coordinated attempts to hack the big players in online services. Hopefully Evernote's encryption methods are solid, but having users change their password at log in is a great way to keep everyone safe. Visit Evernote's blog for more information.



Source: http://feedproxy.google.com/~r/androidcentral/~3/JIk1vtXOPfQ/story01.htm

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Sunday, March 3, 2013

Two new genes linked to amyotrophic lateral sclerosis (ALS) and related disorders

Mar. 3, 2013 ? A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases.

The same mutation occurred in both genes and led to the abnormal build-up of the proteins inside cells. These proteins play an essential role in normal RNA functioning and have also been linked to cancer, including the Ewing sarcoma, the second most common type of bone cancer in children and adolescents. The finding is the latest in a series of discoveries suggesting degenerative diseases and cancer may have common origins. RNA is the molecule that directs protein assembly based on instructions carried in DNA.

The study also adds to evidence that seemingly unrelated neurodegenerative diseases may involve similar defects in RNA metabolism. Researchers linked the problems to a specific region of the mutated proteins whose normal function was unclear. The study was published today in the advanced online edition of the scientific journal Nature.

"I hope this study helps to build the foundation for desperately needed treatments for ALS and perhaps a broad range of diseases caused by abnormal RNA metabolism," said J. Paul Taylor, M.D., Ph.D., an associate member of the St. Jude Department of Developmental Neurobiology and senior author of the study. Taylor and James Shorter, Ph.D., an assistant professor in the biochemistry and biophysics department at the University of Pennsylvania's Perelman School of Medicine, are the study's corresponding authors.

Each year approximately 5,600 people in the U.S. are found to have ALS. The disease is nearly always fatal, often within five years. Patients suffer muscle wasting and paralysis that affects their limbs and trunk as well as their ability to talk, swallow and breathe. There is no cure.

For this project, St. Jude sequenced just the portion of the genome called the exome, which carries instructions for making proteins. Researchers sequenced the exomes of two families affected by rare inherited degenerative disorders that target cells in the muscle, bone and brain. Neither family carried mutations previously tied to ALS or related diseases. The project built on the infrastructure developed by the St. Jude Children's Research Hospital -- Washington University Pediatric Cancer Genome Project, which played an important role in finding the mutations.

Researchers found the families carried a single, previously unknown mutation in a pair of RNA-binding proteins named hnRNPA2B1 and hnRNPA1. The proteins both bind RNA and help regulate its function. When researchers checked for the same mutations in 517 ALS patients they found hnRNPA1 protein mutated in two patients. One patient had the inherited form of ALS. The other ALS patient had no family history of the disease.

The new mutations occurred in a region of the proteins Taylor refers to as a prion-like domain because it has similarities with yeast proteins called prions. Prions are proteins that can alternate between shapes as needed for different functions. "Until recently we did not know these domains existed in humans and now we realize that hundreds of human proteins have them," Taylor said. "We're only beginning to understand their function in human cells."

Researchers showed the prion-like domains are responsible for the shape change that occurs when these proteins convert into slender threads called fibrils. The mutations accelerate fibril formation and recruit normal proteins to form fibrils. This phenomenon called propagation may explain how ALS and related diseases spread throughout the nervous system.

Taylor speculated that the normal function of prion-like domains is to assemble RNAs into temporary structures called granules, which are part of the cell's normal protein production machinery. Granules are normally short lived, and the RNA-binding proteins involved in their formation are recycled. But in cells with hnRNPA2B1 or hnRNPA1 mutation, RNA granules accumulated in the cytoplasm instead of being disassembled. "That's bad news for RNA regulation, which is bad news for those cells," Taylor said.

The study has several important implications, Taylor said. Recognition that the mutations adversely impact regulation of RNA could lead to targeted therapy to correct the problem. The mutation's location in the prion-like domain might also prove significant. Although the mutations in hnRNPA2B1 or hnRNPA1 appear to be rare, hundreds of other RNA-binding proteins have prion-like domains. Taylor said patients with unexplained neurodegenerative diseases may have mutations in these proteins.

The study's first authors are Hong Joo Kim, Nam Chul Kim, Yong-Dong Wang and Jennifer Moore, all of St. Jude; and Emily Scarborough and Zamia Diaz, both of the University of Pennsylvania. The other authors are Kyle MacLea and Eric Ross, both of Colorado State University; Brian Freibaum, Songqing Li, Amandine Molliex, Anderson Kanagaraj and Robert Carter, all of St. Jude; Kevin Boylan, Aleksandra Wojtas and Rosa Rademakers, all of the Mayo Clinic, Jacksonville, Fla.; Jack Pinkus and Steven Greenberg, both of Brigham and Women's Hospital and Harvard Medical School; John Trojanowski, Bradley Smith, Yun Li and Alice Flynn Ford, all of the University of Pennsylvania; Bryan Traynor, of the National Institute of Aging, National Institutes of Health, Bethesda, Md.; Simon Topp, Athina-Soragia Gkazi, Jack Miller and Christopher Shaw, all of the Institute of Psychiatry, London; Michael Kottlors and Janbernd Kirschner, both of University Children's Hospital Freiburg, Germany; Alan Pestronk and Conrad Weihl, both of the Washington University School of Medicine, St. Louis; Aaron Gitler, Stanford University School of Medicine; Michael Benatar, University of Miami Miller School of Medicine; Oliver King, Boston Biomedical Research Institute, Watertown, Mass.; and Virginia Kimonis, University of California-Irvine.

The research was supported in part by the Packard Foundation, by grants (NS053825, AG032953, DP2OD002177 and NS067354) from the National Institutes of Health, the ALS Association, the Ellison Medical Foundation, a grant (MCB-1023771) from the National Science Foundation and ALSAC.

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Story Source:

The above story is reprinted from materials provided by St. Jude Children's Research Hospital.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Hong Joo Kim, Nam Chul Kim, Yong-Dong Wang, Emily A. Scarborough, Jennifer Moore, Zamia Diaz, Kyle S. MacLea, Brian Freibaum, Songqing Li, Amandine Molliex, Anderson P. Kanagaraj, Robert Carter, Kevin B. Boylan, Aleksandra M. Wojtas, Rosa Rademakers, Jack L. Pinkus, Steven A. Greenberg, John Q. Trojanowski, Bryan J. Traynor, Bradley N. Smith, Simon Topp, Athina-Soragia Gkazi, Jack Miller, Christopher E. Shaw, Michael Kottlors, Janbernd Kirschner, Alan Pestronk, Yun R. Li, Alice Flynn Ford, Aaron D. Gitler, Michael Benatar, Oliver D. King, Virginia E. Kimonis, Eric D. Ross, Conrad C. Weihl, James Shorter, J. Paul Taylor. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature, 2013; DOI: 10.1038/nature11922

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/pOZEz9hUe_o/130303154857.htm

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Britain does not rule out future arms to Syria rebels

LONDON (Reuters) - Britain cannot rule out providing arms to Syrian rebels in the future, although a new aid package it will announce this week will consist only of non-lethal assistance, Foreign Secretary William Hague said on Sunday.

Western countries have so far shied away from arming the rebels fighting against President Bashar al-Assad, despite their firm diplomatic backing for efforts to remove him.

Reuters and other news media have reported fighters getting increasingly large shipments of arms through Turkey and Jordan in recent months, with funding for those weapons believed to come from wealthy Arab states, like Qatar and Saudi Arabia.

Washington said on Thursday it would provide non-lethal aid to Syrian rebels to bolster their popular support. The package is expected to include medical supplies, food and $60 million. New U.S. Defense Secretary Chuck Hagel said on Friday he believed giving only "non-lethal support" was correct.

Britain has in the past also offered non-lethal aid to the rebels, such as radios, body armor and medical supplies. Hague is set to make an announcement to parliament this week about more aid, but told BBC television it would not include weapons.

"I will not be announcing this week arms to the Syrian opposition," he said in an interview. "I don't rule out anything for the future.

"If this is going to go on for months or years ... and countries like Iraq and Lebanon and Jordan are going to be destabilized, it's not something we can ignore," Hague added.

"You can reach the point eventually where humanitarian need is so great and the loss of life so great that you have to do something new in order to save lives."

OPTIONS OPEN

Hague has previously said Britain was keeping its options open in Syria, and the Foreign Office said his remarks on Sunday were not intended to signal a shift in policy.

Nevertheless, the question of whether the West will shift to explicit military support is being closely watched at a time when more non-lethal aid is being pledged and Syrian opposition leaders are trying to demonstrate to foreign backers that they can curb the influence of Islamist radicals in their ranks.

In a televised interview with the Sunday Times newspaper shown in London late on Saturday, Assad said Britain's involvement in the Syria crisis was naive and unrealistic.

"How can we expect them (Britain) to make the violence less when they want to send military supplies to the terrorists?" Assad said in the interview.

Hague dismissed Assad's remarks as "delusional".

"This is a man presiding over this slaughter. The message to him is: 'We, Britain, are the people sending food and shelter and blankets to help people driven from their homes and families in his name'," Hague said.

Iran, Assad's main ally, also criticized the West for pledging more aid to fighters.

"The announcement of more help for terrorists by political authorities is a big mistake and they will soon see the results," said Revolutionary Guards commander Brigadier-General Massoud Jazayeri, state news agency IRNA reported on Sunday.

"Some European countries and America who are causing the chaos in Syria will be targeted heavily by these same terrorists. Links between them show that this is a precursor to transferring the agitation from Syria to other places," he said.

Nearly two years of war in Syria has killed 70,000 people and driven millions from their homes. The opposition made major military gains in the second half of 2012 and now controls substantial territory, but is still outgunned by Assad's forces.

Western countries have been loath to arm the fighters, in part because many groups have links to Islamist militants and are seen by the West as potentially dangerous renegades.

In recent months the opposition has set up a unified military command, which rebels have told Reuters is distributing arms and cash sent by foreign backers to units that assure their loyalty, as a way of reining in Islamists.

Hague said he would seek a diplomatic breakthrough during talks with his Russian counterpart, but had little hope for now. Moscow has supported Assad and says his exit from power should not be a pre-condition for a negotiated settlement.

"The Russian foreign minister will be here in London in the next 10 days and of course we will have another major discussion about Syria to see whether we can make some diplomatic breakthrough, but there is no sign of that at the moment, hence we have to do more to try to protect civilian lives in Syria."

(Additional reporting by Marcus George in Dubai; Editing by Peter Graff)

Source: http://news.yahoo.com/britain-does-not-rule-future-arms-syria-rebels-124812476.html

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